Cleveland Browns at Indianapolis Colts: Predictions, picks and odds for NFL Week 7 game

The Cleveland Browns (3-2) are coming off one of the biggest upsets of the season so far and travel to face the Indianapolis Colts (3-3) at Lucas Oil Stadium.

The Browns beat the previously undefeated San Francisco 49ers 19-17 without starting quarterback Deshaun Watson and star running back Nick Chubb. PJ Walker went 18-of-34 for 192 yards and threw two interceptions, but Cleveland's defense held the high-powered 49ers offense to 215 yards. Kicker Dustin Hopkins hit four of his five attempts to capture the win.

The Colts lost a divisional matchup 37-20 to the Jacksonville Jaguars. They also have their starting quarterback out as rookie Anthony Richardson is recovering from a shoulder injury. Gardner Minshew went 33-of-55 for 329 yards and threw a touchdown and three interceptions in the defeat. Star running back Jonathan Taylor only had 19 rushing yards.

PROP TALK: These are the best prop bets for NFL games this week

Colts vs. Browns odds, moneyline, over/under

The Browns are favorites to defeat the Colts, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023.

  • Spread: Browns (-3.5)

  • Moneyline: Browns (-175); Colts (+145)

  • Over/under: 40.5

Not interested in this game? Our guide to the NFL betting odds, picks and spreads has you covered with Thursday Night Football odds, Sunday Night Football odds and/or Monday Night Football odds.

If you’re new to sports betting, don’t worry. We have tips for beginners on how to place bet online. And USA TODAY readers can claim exclusive promos and bonus codes with the online sportsbooks and sports betting sites.

PJ Walker led the Cleveland Browns to one of the biggest upsets of the season so far. They now take on the Indianapolis Colts in Week 7.
PJ Walker led the Cleveland Browns to one of the biggest upsets of the season so far. They now take on the Indianapolis Colts in Week 7.

NFL Week 6 winners, losers: Lions look like legit contender, Giants trip themselves up

NFL Week 7 odds, predictions and picks

Saints vs. Jaguars | Ravens vs. Lions | Bears vs. Raiders | Colts vs. Browns | Patriots vs. Bills | Giants vs. Commanders | Buccaneers vs. Falcons | Rams vs. Steelers | Seahawks vs. Cardinals | Broncos vs. Packers | Chiefs vs. Chargers | Eagles vs. Dolphins | Vikings vs. 49ers

Lorenzo Reyes: Browns 22, Colts 10

In a game that might feature a pair of backup quarterbacks, I’m always going to back the better defense, and Cleveland’s is the best in the NFL. I expect them to pressure Gardner Minshew into turnovers and think the Browns win comfortably.

Tyler Dragon: Browns 21, Colts 17

Cleveland had a stunning win last week against the 49ers. While the Colts are coping with the loss of Anthony Richardson who is probably done for the season. The Browns have the No. 1 defense in the NFL and the team is feeling confident after a huge win.

Victoria Hernandez: Browns 23, Colts 17

Cleveland has probably the biggest momentum in the entire league right now. The Browns showed that they didn’t even need Deshaun Watson to overthrow the mighty 49ers. With Anthony Richardson out and Jonathon Taylor looking like a shadow of himself, the Colts are struggling right now. Cleveland shouldn’t have a problem covering the spread.

Jordan Mendoza: Browns 20, Colts 17

It looks like Gardner Minshew has the keys to the Colts offense for the rest of the season. The Browns defense did spectacularly against San Francisco despite the offense still missing Deshaun Watson, and the unit comes up big again for another win.

Safid Deen: Colts 23, Browns 17

Cleveland’s win over San Francisco last week was impressive, but how much longer can they sustain it without Deshaun Watson (shoulder) and Nick Chubb (out for season). This is the game where Jonathan Taylor reminds us of his prowess as one of the NFL’s best running backs.

You can view the full list of USA TODAY's NFL expert predictions here.

32 things we learned in NFL Week 6: Losses by Eagles, 49ers leave uncertainty at top

NFL salaries: These are the highest paid NFL players

Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. Terms apply, see operator site for Terms and Conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER (NJ, OH), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA), 1-800-9-WITH-IT (IN). Must be 21 or older to gamble. Sports betting and gambling are not legal in all locations. Be sure to comply with laws applicable where you reside.

This article originally appeared on USA TODAY: Cleveland Browns at Indianapolis Colts: Game predictions, picks, odds