Here's why skincare pros can't get enough of polynucleotides - the buzzy new injectable

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What are polynucleotides & why are they trending?Tanja Ivanova - Getty Images

In the ever-evolving realm of injectable skincare, a new contender has emerged: polynucleotides. But what exactly are they, and do they live up to the hype swirling around them, especially in comparison to the renowned Profhilo? We delved into the topic, consulting some of UK's best skincare experts to uncover the truth behind this buzzy new injectable bio-stimulator that's causing a stir.

Meet the Experts

  1. Dr Shaimaa Jamshidi, plastic surgeon, and co-founder of Montrose London

  2. Nurse Nicky Ruebsamen, Head of Injectable Growth at Thérapie Clinic

What are polynucleotides?

'Polynucleotides are made from purified Salmon sperm. An example of a Polynucleotide is ‘DNA’ and is part of the Regenerative Medicine sector.

When Polynucleotides are injected into the skin they expedite the body’s cell regeneration cycle and enhance its repair mechanisms,' reveals Nurse Ruebsamen.

What is in polynucleotides?

DNA fragments extracted from salmon sperm. 'Polynucleotides work on the fibroblast cells (your very own collagen factories) and when injected into your skin your collagen increases. When collagen increases, fine lines and wrinkles reduce and the skin tightens and thickens,' reveals Ruebsamen.

Unlike filler for example, Ruebsamen adds that 'once the polynucleotides have stimulated the fibroblast cells, they disappear and there is no [residue] left within the skin.'

Are polynucleotides better than Profhilo?

According to Ruebsamen, yes. 'Polynucleotides are superior than Profhilo as this is a treatment that does not regenerate or change the skin cells, it hydrates the skin only. Polynucleotides can be injected underneath the eyes for a regenerative effect whereas with Profhilo, this isn’t possible.'

However, that isn't to say Profhilo should be overlooked. Beyond its hydrating and plumping properties, Profhilo also possesses anti-inflammatory and antioxidant qualities, which can help diminish redness, swelling, and other indicators of skin damage.

What area of the body does polynucleotide injections focus on?

'Due to skin around the eyes being thinner, polynucleotide’s most popular use is for treatment of under eyes. However, these DNA polymers can be used on any part of the body dependent on where you would like to see results,' reveals Dr Jamshidi.

Celebrity fans include Katie Piper who recently documented her treatment with Dr Tatiana for Plinest Polynucleotides to help with hydration, skin regeneration and scarring.

Hearst Owned

How quickly can you see results from polynucleotides?

Results are instantaneous. 'At least two treatments are needed to see results from polynucleotides. Changes in skin take between 4-6 weeks to be notice,' says Dr Jamshidi.

What are the side effects of polynucleotides?

There are no serious side effects of polynucleotides, as with all injection treatments the skin may bruise and be slightly swollen due to the trauma caused by the needle. The downtime is around 3-4 days,' says Ruebsamen.

In terms of safety Plinest is the only polynucleotide that carries an CE certification - the European Union’s standard for product safety.

Are there any treatments that complement polynucleotides?

Yes. Dr Jamshidi explains that as this treatment works to improve skin quality, it is great paired with laser and light treatments for an added effect.

'Combining polynucleotides with hyaluronic acid skin boosters to further hydrate the skin also works well.'

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