Mikel Arteta has rallied his Gunners for a fresh title charge after last season's disappointment and a victory on Tyneside could put them top of the table.
A rotated Arsenal side were well beaten by West Ham in the Carabao Cup ahead of the trip north but they will hope that has little bearing on the resumption of league duties.
Newcastle will view things a little differently after swatting aside Manchester United in the same competition on Wednesday night.
After a tricky start, the Toon are unbeaten in six league games and will view this match as a springboard towards another tilt at a top-four finish.
Date, kick-off time and venue
Newcastle vs Arsenal is scheduled for a 5:30pm GMT kick-off today on Saturday November 4, 2023.
The match will take place at St James' Park in Newcastle.
Where to watch Newcastle vs Arsenal
TV channel: In the UK, today's game will be televised live on Sky Sports Main Event and Premier League, with coverage beginning at 5pm.
Live stream: Subscribers can also catch the contest live online via the Sky Go app.
Live blog: You can follow all the action today via Standard Sport’s live blog, with expert analysis from Nizaar Kinsella at the ground.
Newcastle vs Arsenal team news
Newcstle XI: Pope, Trippier, Schar, Lascelles, Burn, Guimaraes, Longstaff, Joelinton, Almiron, Wilson, Gordon.
Subs: Dubravka, Dummett, Ritchie, Krafth, Hall, Livramento, Murphy, Willock, Miley.
Arsenal XI: Raya, White, Saliba, Gabriel, Tomiyasu, Rice, Jorginho, Havertz, Saka, Nketiah, Martinelli.
Subs: Ramsdale, Kiwior, Cedric, Trossard, Vieira, Nelson, Elneny, Hein, Zinchenko.
Newcastle vs Arsenal prediction
What a mighty test this is for both teams.
Newcastle know a win will catapult them back into the top-four picture and continue a fine run of form, whereas Arsenal will want at least a point to continue their title push.
It's a very tough one to predict, but here goes...
Arsenal to win, 1-0.
Head to head (h2h) history and results
The Magpies have won only one of their last 11 meetings with the Gunners.
Newcastle wins: 68
Arsenal wins: 84
Newcastle vs Arsenal match odds
Newcastle to win: 9/5
Arsenal to win: 31/20
Odds via Betfair (subject to change).