Andrew Wadsworth stabbed ex-girlfriend Melissa Belshaw to death at her home in Wigan before launching an attack on her neighbour who tried to help.
South Korean President Moon Jae-in reshuffled his cabinet on Friday as his approval rating sank to a record low amid a backlash over housing policies, rising coronavirus cases, and a scandal involving the justice ministry and top prosecutors. Moon nominated new ministers of interior, health, land and housing, and gender as he sought to refresh his administration, with roughly two years of his presidency to run. Limited to a single term, and holding a small parliamentary majority, there is no obvious risk to Moon's presidency, but the drop in ratings, a resurgence of coronavirus cases and nagging domestic controversies could make it harder for him to fulfil his agenda.
Pierre-Emerick Aubameyang believes Sunday’s north London derby against Tottenham is the perfect moment for Arsenal to kick-start their season. Despite beating Rapid Vienna 4-1 on Thursday night to make it five wins from as many matches in the Europa League, Arsenal have struggled in the Premier League. Next up for Arsenal on Sunday is a trip to face a Spurs side who, unlike the Gunners, have made a flying start and are currently top of the Premier League.
Helsinki, Finland, December 4, 2020 at 11.00 am - QPR has signed an agreement to deliver QPR ProcessAnalyzer to one of the largest logistics companies in Europe The Customer, a leading European logistics company, is currently developing its digital services in order to increase efficiency across business areas. The Customer will use QPR ProcessAnalyzer to support its digital transformation, starting by optimizing procurement processes such as Procure-to-Pay (P2P). In order to get the needed transparency into its multi-business strategy and individual processes occurring over various geographical and functional areas, the Customer realized the need for process mining. QPR ProcessAnalyzer was selected because of its enterprise compatibility, powerful analytics abilities and advanced dashboarding functionality. By analyzing data from multiple source systems, the Customer will be able to get a holistic view of its processes, with full coverage of process steps and transactions. This also enables the Customer to understand root causes of inefficiencies and identify where it is most profitable to optimize processes and implement process automation. “We are excited to work together with this company that operates in a variety of areas, all of which can benefit from process mining. The good thing is that in these financially challenging times, companies can increase their efficiency substantially without changes in their headcount, by optimizing their processes. We have witnessed companies radically transform their business once they’ve realized the benefits of process mining, and I am thrilled to see this company start its process mining journey with us”, says Senior Vice President Matti Erkheikki who manages the process mining business at QPR Software. About QPR Software QPR Software Plc (Nasdaq Helsinki) provides process mining, performance management and enterprise architecture solutions for digital transformation, strategy execution, and business process improvement in over 50 countries. QPR software allows customers to gain valuable insights for informed decisions that make a difference. Dare to improve. www.qpr.com For additional information in QPR Software, please contact: Matti Erkheikki Senior Vice President, QPR Software Plc E-mail: email@example.com Tel. +358 40 717 2570
When reflecting on a hugely successful career, fans are an intrinsic part of Cole’s greatest memories
Italy visit Llanelli on Saturday desperate to end a 14-game losing run against Wales.
A scientist has explained why starfish will risk being eaten to have gay sex, as it makes reproductive sense.
Migrants must learn English and have relevant employment skills, Leave campaigners say
Dublin, Dec. 04, 2020 (GLOBE NEWSWIRE) -- The "Seasonal Influenza Vaccines" report has been added to ResearchAndMarkets.com's offering. The seasonal influenza vaccines market in the US, Japan, and five major European markets (France, Germany, Italy, Spain, and the UK) is expected to continue to expand over the next 10 years, largely due to the continued uptake of premium-priced vaccines in the elderly subgroup, including quadrivalent forms of Fluzone High-Dose (HD) and Fluad, as well as the launch of the first-in-class adjuvanted nanoparticle vaccine, NanoFlu. Further to this, an aging population in the US, Japan, five major European markets, and other developed countries will increase the number of patients in the 65 years age group, where coverage rates are higher. Additionally, the COVID-19 pandemic has prompted an unexpected surge in demand for influenza vaccines due to heightened public awareness of the threat posed by respiratory viruses to the elderly and those with co-morbidities, as well as the potential burden on healthcare services of coinciding COVID and influenza waves.Three major manufacturers dominate the seasonal influenza vaccines market, namely GlaxoSmithKline, Seqirus, and Sanofi, with 2019 vaccines sales of $684m, $799m, and $2,144m, respectively. Each company saw increased sales in 2018 and 2019, with GlaxoSmithKline (Fluarix and Flulaval), Sanofi (Fluzone, Fluzone HD, Vaxigrip, and Flublok), and Seqirus (Afluria, Agrippal, Fluad, and Flucelvax) growing by 3%, 7%, and 19%, respectively. Additionally, AstraZeneca is a minor player in the market with only one marketed vaccine, FluMist QIV, which has struggled since negative CHMP recommendations in the 2016/17 and 2017/18 seasons, as well as manufacturing issues in the 2019/20 season.Vaccines produced by the traditional egg-based method including Afluria/Agrippal (CSL), Fluarix/Flulaval (GlaxoSmithKline), and Fluzone/Vaxigrip (Sanofi) collectively hold the greatest share of the seasonal influenza market and are primarily used outside of the lucrative elderly subgroup, where other vaccines that have demonstrated superior effectiveness to standard dose inactivated vaccines (Fluzone HD, Fluad, Flucelvax, and Flublok) have been gaining increasing uptake in recent years. As there is no differentiation between the standard dose inactivated vaccines with regard to effectiveness or safety, uptake is primarily based on marketing and manufacturing capabilities, as well as competitive tendering processes. Egg-based vaccines have the disadvantage of long production timelines, and the viral HA antigens are prone to mutations during the egg-based replication process. On the other hand, recombinant or cell-based vaccines have faster production timelines and a reduced risk of HA mutations, leading to potentially superior protection.There are two non-egg-based vaccines on the market, Sanofi's recombinant HA protein vaccine Flublok QIV, and Seqirus's cell-based vaccine Flucelvax QIV, with the latter having the benefit of a broader label in the US (individuals aged 4 years versus aged 18 years for Flublok). There is growing evidence that Flublok's and Flucelvax's egg-free production process (and subsequent lack of egg-based mutations that can lead to the produced HA antigens differing from those of circulating strains) results in superior real-world effectiveness compared to inactivated egg-based vaccines, particularly in the elderly where vaccine effectiveness is suboptimal. Both Flucelvax QIV and Flublok QIV are expected to experience sales growth following anticipated regulatory approvals in the EU in Q4 2020. Approval of Flublok QIV in the EU will allow the vaccine to compete against Flucelvax QIV, Fluad QIV, and Sanofi's own Efluelda QIV in the elderly segment from the 2021/22 season, where all vaccines have shown evidence of increased effectiveness compared to standard dose inactivated vaccines.The 2020 EU approvals of CSL's Fluad QIV and Sanofi's Fluzone HD QIV mark significant opportunities for both manufacturers. Within Europe, Fluad possesses first-to-market advantage and benefits from a preferential recommendation for use in the elderly in the UK. Historical manufacturing capacity issues prevented Sanofi from marketing Fluzone HD outside of the US, but after investing in increasing its manufacturing capacity, Sanofi has now decided to market the vaccine in additional regions including Europe, posing a significant threat to Fluad's European dominance of the elderly segment. Given the lack of head-to-head trials comparing Fluad and Fluzone HD, competitive pricing will be paramount for Fluad to maintain its market share.NanoFlu, a first-in-class nanoparticle vaccine, is the most advanced asset in the influenza pipeline. Novavax expects to file a BLA in Q4 2020, with subsequent approval in mid-2021 (due to fast track status), and a probable launch in the 2022/23 influenza season. The vaccine will be approved based on a Phase III trial showing superior immunogenicity in the elderly compared to standard dose Fluzone; however, a confirmatory efficacy study post-approval will be required, most probably against Fluzone HD. Based on promising immunogenicity against both vaccine homologous and historically drifted strains, the publisher expects NanoFlu will be a strong competitor for Fluzone HD, Flublok, and Fluad in the elderly segment, but much will depend on the outcome of the confirmatory efficacy study as some physicians/payers will not be willing to infer that improved immunogenicity necessarily results in improved real-world protection.There is a high unmet need in the influenza space for a universal influenza vaccine which offers protection against a broader variety of strains, ideally over several seasons, though at this stage it is unclear how long any protective effect would last. Additionally, universal vaccines should be able to provide protection against new pandemic strains that may arise, which the seasonal influenza vaccine is unable to do. Despite positive immunogenicity data from Phase I and Phase II clinical trials, in October 2020 BiondVax reported that its universal vaccine candidate M-001 had failed to demonstrate efficacy in its pivotal Phase III trial. Based on these negative data and the company's lack of funding to initiate a new trial, the publisher expects that BiondVax will discontinue the vaccine shortly. Although Imutex's FLU-v is now the most advanced universal vaccine in development, progress is currently stalled while the company seeks a partner to fund a pivotal trial, and therefore it seems that the earliest a universal vaccine will reach the market is 2024. Key Topics Covered: OVERVIEW Latest key takeaways DISEASE BACKGROUND DefinitionSymptomsRisk groups RECOMMENDED VACCINESUS Five major European marketsSeasonal influenza vaccination recommendations, by country MARKETED VACCINESPIPELINE VACCINESKEY REGULATORY EVENTS Sanofi Seeks Double Vaccine Approval Nod In EUFDA Clears CDC Diagnostic For COVID-19 And InfluenzaAudenz Brings Cell-Based Manufacturing To Pandemic Influenza PROBABILITY OF SUCCESSCLINICAL TRIAL LANDSCAPE Sponsors by statusSponsors by phaseRecent events VACCINE ASSESSMENT OverviewStandard dose, egg-based inactivated vaccinesLive-attenuated vaccineVaccines for the elderlyPipeline vaccinesUniversal influenza vaccinePipeline live-attenuated vaccine MARKET DYNAMICSFUTURE TRENDS Completion of conversion to QIVs will drive incremental growthRetrospective analysis showing superior effectiveness of Fluzone HD to Fluad in the elderly will help Sanofi retain US market shareNanoFlu is expected to achieve high uptake due to its superior efficacy over standard influenza vaccinesUniversal vaccines could begin to replace the current standard of care CONSENSUS FORECASTSRECENT EVENTS AND ANALYST OPINION NanoFlu for Seasonal Influenza Vaccines (March 24, 2020) KEY UPCOMING EVENTSUNMET NEEDSBIBLIOGRAPHY Prescription information APPENDIX For more information about this report visit https://www.researchandmarkets.com/r/tbkku2 Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research. CONTACT: CONTACT: ResearchAndMarkets.com Laura Wood, Senior Press Manager firstname.lastname@example.org For E.S.T Office Hours Call 1-917-300-0470 For U.S./CAN Toll Free Call 1-800-526-8630 For GMT Office Hours Call +353-1-416-8900
The five-year budget, which runs to 2024 has been cut from £10.4bn to £9.4bn, rail minister Chris Heaton-Harris said.
Back in October, legendary fund manager Nick Train bought a new share for his portfolio. Now, Edward Sheldon has just bought the FTSE 100 stock himself. The post I just bought Nick Train’s new FTSE 100 stock appeared first on The Motley Fool UK.
America’s top infectious disease has apologized for suggesting U.K. authorities rushed their authorization of a COVID-19 vaccine, saying he has “great faith” in the country’s regulators. Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, had sparked controversy with an earlier interview in which he said U.K. regulators hadn’t acted “as carefully” as the U.S. Food and Drug Administration. Fauci told the BBC: “I do have great faith in both the scientific community and the regulatory community at the U.K., and anyone who knows me and my relationship with that over literally decades, you know that’s the case.”
The final three will battle it out to be crowned the first King or Queen Of The Castle.
UK vows to outdo other economies with 68% emissions cuts by 2030Boris Johnson promises to go further and faster by setting target of 68% reduction in annual carbon emissions
Most years, the company holiday party is a chance to do everything from witness your boss getting a little too drunk and making a heartfelt, misty-eyed speech to maybe catch a glimpse of your coworkers’ significant others. Even if you’ve never been to a company holiday party, you know what they’re like thanks to television shows making the annual event a common trope. Throughout its nine seasons, The Office showed us many different ways holiday get-togethers can devolve into an awkward mess, and in Mad Men, office parties were an excuse for everyone to get even drunker than usual. At one memorable work fete, a secretary rides a lawnmower through the office and, well, let’s just say that enough blood gets spilled that watching this episode is certainly enough to turn you off from work parties for good. But, there will be few, if any wild holiday party hijinks this year. In a study of 189 companies across industries in the US conducted by outplacement firm Challenger, Gray & Christmas, only 23% said they would be marking the end of the year in some way. Among that 23%, almost three quarters said it would be some kind of virtual event — through Zoom, Google Hangouts, Microsoft Teams, or whatever the company’s video conferencing program of choice may be. “Since we can’t safely host our normal holiday party, we’re planning on a virtual celebration complete with customised gift baskets for each employee,” says Jenna Saponaro, chief of staff at marketing agency Postali. “We’ve partnered with a local courier service who will deliver the baskets within a two-hour time frame while we’re having our virtual party. We’ll have time set aside for the team to meet in small groups — as if they were mingling at an actual party — and then we’ll also spend some time as an entire group, and throughout the evening, the team will be answering their doorbells to a surprise gift, which will also include their end-of-year bonus checks.” But there’s also, understandably, a lot of Zoom fatigue by now. It doesn’t matter how great your internet connection is — video chatting just isn’t the same as face-to-face socialising, and sitting at home in front of your computer is a far cry from a party at a venue where there’s a DJ and a dance floor. In light of this, some companies are refocusing on what might be the best alternative to a holiday party for their employees. “Normally we do have an office party, and being a company of only 30-40 people, it wasn’t very hard to get everyone together or invite plus-ones for a formal dinner,” says Sarah Sherren, who works at product and service review site Best Company. “This year, however, our CEO has just decided to give every employee paid leave from Christmas through the New Year. I love a good holiday party, but honestly, giving paid time off for employees to celebrate however they can or want is much nicer than making small talk with coworkers I don’t know very well.” Elizabeth, 20, works as a paralegal in Kansas City and is also happy about the pivot her workplace is making this year. “They’re sending all of us turkeys to our house!” she says. “In the years I’ve been with the company, they’ve always been very generous — think year-end bonuses and bonuses when we hit certain sales milestones — but they’ve never given us turkeys before.” She notes that she’s definitely not a fan of Zoom parties. Terry, 29, works in marketing in Denver. “We’re an employee-owned company, so it was decided as a group that in place of a party we’re using our budget to give everyone a gift card for the holidays. I feel like this was a safe and equitable alternative,” she says. “My partner jokes that I’m always getting free money from my work. We have a designated budget for employee engagement and spot bonuses for safety — so it’s not uncommon to have some sort of gift card program circulating.” Like others, Terry doesn’t particularly enjoy Zoom get-togethers. “The sales team tries to loop in marketing on a weekly celebration call, but it usually turns to venting and I often have to skip it because of my work deadlines. I’m okay with that.” And while many people seem to agree that Zoom parties are lacklustre, in-person work parties can be a minefield of awkwardness or bad behaviour. Rachel, 28, works in politics in Chicago. “Our boss gave everyone gifts and clearly gave better gifts, and more gifts, to people he liked more,” she recalls of the worst work holiday party she attended. Mallory, 29, currently works in social media in New York City. “A few years ago, I was working at a PR agency and we all went out for dinner and karaoke,” she says. “My boss got super hammered and kept pressuring everyone to go to the bathroom and do coke. A few girls I worked with gave in and did it. I refused and left early, and I felt hardcore judged for months. I only stayed for about six months after that. My boss, although a nice person, was not financially savvy and eventually blew through all of her parents’ money, which she was using to fund the business.” All this leads to the question of whether we should have holiday office parties even when the pandemic is over. Could they, like fax machines, become a workplace relic? What purpose do they really serve — and how could they evolve? Erica Keswin, a workplace strategist who has written a book on the importance of workplace rituals called Rituals Roadmap: The Human Way to Transform Everyday Routines into Workplace Magic, believes that they do still serve a purpose — when they’re done the right way. She points out that the end-of-year work celebration “is a time for many organisations to have people come together and bring a significant other. I think that was a big part of it — we’re keeping your person here, they’re working all the time and we want to thank you as well. It’s to create an additional bond with the broader family, because they know that to get the person that works there really focused, you need to have a support system around that person.” This may be a part of why work parties can be so discomfiting. The point is to help you bond, to welcome a part of work into your personal life and vice versa, but that’s not something we necessarily want to do. Before COVID-19, the boundary between work and home for most people was physically distinct. Our commutes weren’t just about bridging the physical distance between home and work, but were also about transitioning in body and spirit from one space to the other. Many of us want that delineation, because it helps set up a healthy boundary between the personal and the professional. But the essence of the work party is an uncomfortable union of the two dominant compartments of your life: your work self and your “real” self. A resistance to these worlds colliding is why some people maintain a solid border between friends and work-friends. “It’s nice to be able to have close coworkers, but I firmly keep them in the coworker sphere,” says Rachel. Terry agrees that there are limits to a coworker friendship. “I have good work relationships built on trust, but I wouldn’t share anything too personal,” she says. “I’m very careful about what I share — for instance, I would never share with a coworker that I’m in therapy. I’m not embarrassed or ashamed, I just like having a divide between my professional and personal life and having parts of me that are just for me.” A survey of 3,000 people by Olivet Nazarene University found that 41% of people categorised those they worked with simply as “coworkers,” while 20% said they were “only-at-work friends.” Only 15% answered that some of their coworkers were “real friends.” And yet, while some of us may keep our work relationships at a distance, it’s undeniable that during quarantine we’ve been lonely and longing for more connection, not less. “I personally have been someone that has developed, over the years, real friendships at work,” says Keswin. “Many of us spend more time at work than we do at home, which is why so many people are so lonely right now.” This is why bonding rituals that bring emotional honesty to your coworker relationships can be so crucial — whether it’s a holiday party or otherwise. She notes that, this year, more companies are looking to ensure that their holiday celebrations really express their values, and the sincerity of their appreciation for employees. The general lack of enthusiasm people show for work parties is a chance to “rethink everything about the way we work.” In terms of holiday parties, that might mean respecting people’s time by scheduling the event during work hours — not at 9pm on a weeknight — and keeping it fairly short. “One company I spoke to said, ‘How do we involve the family?’” says Keswin. “Let’s hire a virtual Santa to read to the kids in a breakout room, so that employees don’t have to hire a babysitter to come to their virtual holiday.” A company could also “celebrate” the holidays by communicating their values through a well-placed gift to a charity or other organisation for social good. Especially given that companies can’t throw an expensive in-person party this year anyway, “Why not use that budget to do something that’s better for the world?” says Keswin. It would set a positive example for employees and help reinforce that, hey, you’re actually working for a decent place that puts its money where its mouth is. “[We] want to feel connected to people,” she says. “Rituals give us what I call the three Ps: psychological safety, purpose, and both of those together give us a boost of performance. ‘Performance’ can mean that we feel better emotionally [while working], which will give us that sense of belonging that people are craving.” “One of the things I talk about and have been thinking about a lot recently is the importance of matching the message to the medium,” says Keswin. That means if you’re serious about connecting and communicating a message to your employees, Zoom just can’t be the sole medium through which you deliver that message. People will get tired, both physically and mentally. “It has a diminishing return in terms of connection,” she says. She suggests creating a diversity of ways to connect. “Have a Slack channel and connect on your favourite NBA team, or pictures of your dog or pictures of your kids. Have certain days where you’re talking to somebody on the phone.” One of the chapters of Keswin’s upcoming book focuses on a concept called “eatings” — like meetings, but meetings where you eat together over video chat during these isolated times. She cites online course provider Udemy, which has a ritual called “lunch roulette,” in which people could sign up to be randomly matched with colleagues to have lunch with a different group of people every other Thursday. “[Udemy] shared with me that people miss this ritual so much that they adapted it for COVID,” Keswin says. She says that “lunch roulette” highlights the key to what makes rituals different from just a habit. “Not every lunch on Zoom is a ritual,” she says. “There’s a higher level of intention and purpose around why they’re doing it to begin with.” It sets the tone for the company’s values and culture, and it also brings a routine into your workflow that consistently nurtures your work relationships. While Keswin believes that post-COVID, we’ll see a permanent move away from spending so much time in the office, she says that the pandemic WFH era has been manageable in large part because we knew our colleagues and managers beforehand. “We have been living off the relationship capital that we have built over the years,” she says. “You have all these colleagues that you can vent to and laugh with and bond with because you’re home — but you’re able to do that more effectively because you know them from the office.” In the end, a work holiday party is — like a family holiday party — about fostering your interpersonal relationships. “If it were what I would want [this year]? I would want people to come together and hear from leaders,” Keswin says. “Leaders should use this opportunity to give a state of the union, address the company, and really have this be a moment of gratitude, to thank people for what they’ve done.” That appreciation could take the form of being sent a Thanksgiving meal on the company’s dime or getting extra vacation days to recover from burnout — anything as long as it’s not another Zoom call. Like what you see? How about some more R29 goodness, right here?"Zoom Dick" Jokes Are Easy, But They're Not Okay5 Zoom Hairstyles That Will Become WFH StaplesWhy Am I So Afraid Of Saying No To Zoom Calls?
Nearly 10% has been wiped off the organisation's infrastructure budget.
Henry Blake has made a gripping, timely drama out of a real life crisis
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In this week’s selection of the latest films made available to streaming, expect some reflection on the injustices of Hollywood cinema.
India says it has summoned the Canadian High Commissioner in Delhi to protest against comments made by prime minister Justin Trudeau about the ongoing farmer protests outside the Indian capital. Tens of thousands of protesters have marched upon Delhi from farms in neighbouring states of northern India to criticise new reforms that will open up the agricultural sector to privatisation and market forces. Mr Trudeau said earlier this week that the situation was “concerning” and that Canada would always “defend the right to peaceful protest”.