The series - based on the hit Belgian series of the same name - is set against the backdrop of Cambridge university, with Ben playing genius OCD criminologist, Professor Jasper Tempest alongside Tony Award-winner Frances as his colourful but overbearing mother, Adelaide.
Emerging actress of the screen and stage Emma Naomi takes up the role of Detective Inspector Lisa Donckers with rising star Barney White cast as her police sidekick Dan Winters.
The series will be directed by leading Belgian director, Indra Siera, and will be filmed in Belgium and Cambridge during the summer of 2020.
The drama is from newly formed production company, Eagle Eye Drama, launched by the same team behind global drama brand Walter Presents.
Executive Producer and CEO of Eagle Eye Drama Walter Iuzzolino said in a statement: "Professor T is my all-time favourite detective – a tortured genius wrestling with a mystery childhood trauma.
"It's a unique crime series with a core of wonderful warm characters at its heart and I am delighted to be working with our hand-picked European production team to make this for ITV and international audiences."
Meanwhile, Ben Miller - who starred as DI Richard Poole in BBC1's hit series Death in Paradise - will also feature in Netflix's anticipated period drama Bridgerton from award-winning executive producer Shonda Rhimes.
Bridgerton arrives to Netflix later this month.
Professor T will air on ITV.
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