The comedian, who has had a few pops at politicians in the past, dabbles in art and chose the prime minister for his latest piece.
He has now shared the image – which was emblazoned with the words "f****** hell" – on Instagram.
The star explained that he did it while at an event in aid of SIFA Fireside, a charity that helps the homeless in Birmingham.
Lycett, who is from the city, wrote: "While diners enjoyed the fruits of my small garden and the genius of the kitchen I sat in the corner of the restaurant painting.
"One of the paintings was of the Prime Minister, who across the city was refusing to tell journalists if she would support raising benefits in line with inflation, a policy which will undoubtedly affect and likely increase the homeless population of this country.
"IN LIZ WE TRUSS, BABY!!!"
The star, 34, thanked those involved in the event, and carried on: "If you can support SIFA Fireside please do, but don’t get me involved I’m incredibly right wing and am sick to the back teeth of those bloody scroungers."
Lycett has been pretty outspoken when it comes to politics.
During a recent appearance on the BBC's new flagship politics programme Sunday With Laura Kuenssberg, he amused his fans when he claimed to be a “very right-wing” Tory supporter who was a fan of Truss.
Earlier this year he tickled fans when he penned his own light-hearted version of Sue Gray’s report into the alleged Downing Street lockdown parties.
Watch: Tory MP discusses Joe Lycett mocking Liz Truss in parliament