Cancer charities have signed an open letter urging the public to keep vulnerable people safe despite "Freedom Day".
From Monday, social distancing is no longer mandatory in England, while requirements for face coverings in shops and on public transport will be less stringent.
There are no limits on the number of individuals that you can meet, although people are still encouraged to meet outside if possible to reduce Covid-19 transmission rates.
The Blood Cancer UK website has shared a letter, with 40 signatories including CEOs and directors at Cancer Research UK, Macmillan Cancer Support and the Roy Castle Lung Cancer Foundation, warning that for those living with cancer, their illness or treatment reduces the effectiveness of the vaccine, even after two doses.
The letter states: "We had hoped the Government would continue to insist people carry on wearing masks and social distancing in crowded places."
Charities have urged the public to do three things: keep wearing masks in crowded places, keep your distance from strangers, and get vaccinated if you have not done so already.
"Just one person doing these three things could make a real difference to someone with cancer," the letter reads. "And the more of us who do them, the more we will help keep people with cancer safe, and send them a message of solidarity during the difficult weeks ahead."
They note the importance of these guidelines in England, where restrictions are being lifted first, but Scotland, Wales and Northern Ireland will ease their own rules over the next two months.