The date was revealed in a special launch video, which you can watch above, featuring celebrities including Dame Judi Dench, Benedict Cumberbatch, Joe Sugg, Roman Kemp and Katherine Ryan.
This year's event has the tagline "funny is power", and the video features the celebs talking about times in their lives that laughter has helped them get through.
Cumberbatch says: "I think laughter is a panacea, it is and has always been a national medicine.
"I think people reached out for it in lockdown. It was a comedy rather than a tragedy that people first went for."
While Dench adds: "I have got myself into trouble more times than I can tell you by laughing in very serious moments."
Speaking about this year's event in light of the Covid-19 pandemic, Comic Relief co-founder Lenny Henry said: "We know that it's hard financially for so many people right now, but we'd love you to join us – even if it's just to share a laugh.
"If we raise some money along the way then brilliant. We know that when times are tough, laughter can really make a difference."
The 2021 event marks the 35th in Comic Relief's history and the BBC One telethon will be hosted by Alesha Dixon, David Tennant, Davina McCall, Paddy McGuinness, and Lenny Henry.
And as usual, you can expect a host of performances and sketches, including a Vicar of Dibley special with Dawn French, and David Tennant and Michael Sheen starring in a special edition of Staged.
Comic Relief: Red Nose Day airs on Friday, March 19 on BBC One. You can make a donation at comicrelief.com/rednoseday
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