Hyperemesis gravidarum, the condition that Schumer is experiencing, also affected the Duchess of Cambridge during all three of her pregnancies.
While nausea and sickness is common during the first 14 weeks of pregnancy, hyperemesis gravidarum affects around one in 100 pregnant women and involves acute cases of nausea and vomiting, the NHS explains.
A person with the debilitating condition may vomit up to 50 times a day, and could be at risk of low blood pressure, dehydration and ketosis, a metabolic state that occurs when there isn't enough glucose for the body to break down and use as fuel.
Schumer, who announced that she is expecting her first child with husband Chris Fischer last month, has discussed having to cancel stand-up performances in Texas due to the condition.
Posting a photo of herself in a hospital bed on Instagram, the comedian apologised to those who were expecting to see her at the shows.
“I am in the hospital. I’m fine. Baby’s fine but everyone who says the second trimester is better is not telling the full story,” she writes.
“I’ve been even more ill this trimester. I have hyperemesis and it blows.”
She also thanked the doctors and nurses for taking care of her in the post.
For anyone who's experiencing hyperemesis gravidarum, Baby Centre UK advises accepting cravings for certain foods, avoiding sights or smells that may make you feel nauseous, staying hydrated and eating regularly in small quantities.
A number of people have been sending their well-wishes to Schumer underneath her Instagram post.
"Sorry you're feeling ill. Rest up, your body needs it," writes Guardians of the Galaxy actor Zoe Saldana.
"Oh mama. Feel better soon!" writes 8 Simple Rules actor Amy Davidson. "Growing a human is no joke!"
When the news of the Duchess of Cambridge's pregnancy was announced in 2017, Kensington Palace revealed that she was experiencing the same condition for a third time.
"As with her previous two pregnancies, the duchess is suffering from hyperemesis gravidarum," the statement issued by the palace read.
"The duchess is being cared for at Kensington Palace."