More than 10,000 ambulance workers have voted to strike in England and Wales, the GMB union has announced.
It said: "No one in the health service takes strike action lightly – today shows just how desperate they are."
Paramedics, emergency care assistants, call handlers and other staff are set to walk out in nine trusts:
South West Ambulance Service
South East Coast Ambulance Service
North West Ambulance Service
South Central Ambulance Service
North East Ambulance Service
East Midlands Ambulance Service
West Midlands Ambulance Service
Welsh Ambulance Service
Yorkshire Ambulance Service
The industrial action is set to take place before Christmas, with the union planning to meet reps in the coming days to discuss potential dates.
The GMB said workers across the ambulance services and some NHS trusts have voted to strike over the government's 4% pay award, which it described as another "massive real-terms pay cut".
"Ambulance workers – like other NHS workers – are on their knees," said the union's national secretary, Rachel Harrison.
"Demoralised and downtrodden, they've faced 12 years of Conservative cuts to the service and their pay packets, fought on the front line of a global pandemic and now face the worst cost of living crisis in a generation."
The union has assured the public that "patients will always come first" and emergency cover will be available during the walkout.
Health Secretary Steve Barclay said he "deeply" regrets ambulance staff striking and said it is "in nobody's best interests as winter approaches".
But he insisted: "Economic circumstances mean unions demands are not affordable - each additional 1% pay rise for non-medical staff would cost around £700m a year.
"My door is open to discuss with unions ways we can make the NHS a better place to work.
"Our priority is keeping patients safe during any strikes and the NHS has tried and tested plans to minimise disruption and ensure emergency services continue to operate."
What other strikes are due to take place?
The strike comes after the UK's biggest trade union, Unison, announced thousands of its ambulance workers in England also intend to take industrial action before Christmas.
Up to 100,000 nurses from the Royal College of Nursing are also set to stage a mass walkout in December – one of the busiest months for the NHS.
The army has already been placed on stand by in case it is needed to fill the roles of NHS workers while strikes are taking place.
Several strikes are also taking place across other sectors, with Eurostar security staff announcing earlier on Wednesday that they will be taking part in a walkout next month in a dispute over pay.
Members of the Rail, Maritime and Transport union at Network Rail and 14 train operators are striking in December and January as well.